MerTK/Axl-IN-1
MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual MerTK/Axl inhibitor, with IC50s of 4.2 and 8.8 nM in Ba/F3, and 0.2 and 0.9 nM in HTRF. MerTK/Axl-IN-1 results in pMerTK inhibition in vivo. MerTK/Axl-IN-1 has long half-life, high oral exposure and bioavailability[1].
Product Specifications
CAS Number
3036009-40-9
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mertk-axl-in-1.html
Smiles
FC1=NC=CC=C1C2=CC(C(N[C@H]3CCC[C@@H]3OCC4=CC=C(C5=CC(CCC[C@@H]6N7CCN(C[C@@H](CO)O)CC7)=C6C=C5)C=C4)=O)=C(N)N=C2
Molecular Formula
C40H47FN6O4
Molecular Weight
694.84
References & Citations
[1]Yu Y, et al. Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor. J Med Chem. 2024 Sep 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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