Paroxetine (hydrochloride hemihydrate)

Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.

Product Specifications

CAS Number

[110429-35-1]

Product Name Alternative

BRL29060 (hydrochloride hemihydrate) ; BRL29060A (hemihydrate)

UNSPSC

12352211

Hazard Statement

H302, H317, H319, H335, H410

Target

Autophagy; G Protein-coupled Receptor Kinase (GRK) ; Serotonin Transporter

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Paroxetine-hydrochloride-hemihydrate.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1[C@H](CCNC2)[C@@H]2COC3=CC=C(OCO4)C4=C3.Cl.[0.5H2O]

Molecular Formula

C19H22ClFNO3.5

Molecular Weight

374.84

Precautions

H302, H317, H319, H335, H410

References & Citations

[1]Wang Q, et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28;7:45364.|[2]Lassen TR, et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112 (3) :26.|[3]Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60 (7) :3052-3069.|[4]Liu RP, et al. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation. 2014 Mar 12;11:47.