Pneumolysin-IN-1
Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM) . Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae[1].
Product Specifications
CAS Number
330842-49-4
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pneumolysin-in-1.html
Purity
98.08
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(N(C2=CC(C)=CC(C)=C2)C(/C1=C/C3=CC=C(C4=C(Cl)C=C(Cl)C=C4)O3)=O)=O
Molecular Formula
C23H16Cl2N2O4
Molecular Weight
455.29
References & Citations
[1]Aziz U B A, et al. Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins[J]. Nature Communications, 2024, 15 (1) : 3537.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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