TH (phospho Ser19) Polyclonal Antibody

Rabbit Anti-TH (phospho Ser19) Polyclonal Antibody

Product Specifications

Background

Tyrosine hydroxylase encoded by TH is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in TH have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for TH.

CAS Number

9007-83-4

Product Name Alternative

TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH

Gene ID

7054

Accession Number

P07101

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human TH around the phosphorylation site of S19

Clonality

Polyclonal

Tag

Tyrosine 3-monooxygenase

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

45kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-TH (S19) Polyclonal Antibody detects endogenous levels of TH protein only when phosphorylated at S19.

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.