GABAA Rβ1 (phospho Ser434) Polyclonal Antibody

Rabbit Anti-GABAA Rβ1 (phospho Ser434) Polyclonal Antibody

Product Specifications

Background

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system.GABRB1 encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of GABRB1 is implicated in the pathogenetics of schizophrenia.

CAS Number

9007-83-4

Product Name Alternative

GABRB1; Gamma-aminobutyric acid receptor subunit beta-1; GABA (A) receptor subunit beta-1

Gene ID

2560

Accession Number

P18505

Reactivity

Human, Mouse, Rat, Monkey

Immunogen

Synthesized peptide derived from human GABAA range: Rβ1 around the phosphorylation site of S434

Clonality

Polyclonal

Tag

Gamma-aminobutyric acid receptor subunit beta-1

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

55kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-GABAA Rβ1 (S434) Polyclonal Antibody detects endogenous levels of GABAA Rβ1 protein only when phosphorylated at S434.

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200