Hrs (phospho Tyr216) Polyclonal Antibody

Rabbit Anti-Hrs (phospho Tyr216) Polyclonal Antibody

Product Specifications

Background

Hepatocyte growth factor-regulated tyrosine kinase substrate encoded by HGS regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. Hepatocyte growth factor-regulated tyrosine kinase substrate sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.

CAS Number

9007-83-4

Product Name Alternative

HGS; HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110

Gene ID

9146

Accession Number

O14964

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human Hrs around the phosphorylation site of Y216

Clonality

Polyclonal

Tag

Hepatocyte growth factor-regulated tyrosine kinase substrate

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

115kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-Hrs (Y216) Polyclonal Antibody detects endogenous levels of Hrs protein only when phosphorylated at Y216.

Observed Molecular Weight

115

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.