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HDAC8 (phospho Ser39) Polyclonal Antibody

Rabbit Anti-HDAC8 (phospho Ser39) Polyclonal Antibody

Product Specifications

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 8 encoded by HDAC8 belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for HDAC8.

CAS Number

9007-83-4

Product Name Alternative

HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

Gene ID

55869

Accession Number

Q9BY41

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human HDAC8 around the phosphorylation site of S39

Clonality

Polyclonal

Tag

Histone deacetylase 8

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-HDAC8 (S39) Polyclonal Antibody detects endogenous levels of HDAC8 protein only when phosphorylated at S39.

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200

Other Product Names

HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q9BY41

Isotype

Rabbit IgG

Available Sizes

Frequently Asked Questions

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