Naringenin chalcone

Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties[1][2][3][4][5][6].

Product Specifications

CAS Number

[73692-50-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Drug Intermediate; NO Synthase

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/naringenin-chalcone.html

Concentration

10mM

Purity

99.29

Solubility

DMSO : 50 mg/mL (ultrasonic) |Methanol : ≥ 25 mg/mL

Smiles

OC(C=C1)=CC=C1/C=C/C(C2=C(C=C(O)C=C2O)O)=O

Molecular Formula

C15H12O5

Molecular Weight

272.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Hirai S, et al. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci. 2007 Sep 29;81 (16) :1272-9. |[2]Iwamura C, et al. Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol Int. 2010 Mar;59 (1) :67-73.|[3]Zhang S, et al. Anti-cancer effect of naringenin chalcone is mediated via the induction of autophagy, apoptosis and activation of PI3K/Akt signalling pathway. Bangladesh Journal of Pharmacology, 2016, 11 (3) : 684-690.|[4]Horiba T, et al. Naringenin chalcone improves adipocyte functions by enhancing adiponectin production. Mol Cell Endocrinol. 2010 Jul 29;323 (2) :208-14. |[5]Escribano-Ferrer E, et al. In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice. J Nat Prod. 2019 Feb 22;82 (2) :177-182. |[6]Yoshimura M, et al. Identification and quantification of metabolites of orally administered naringenin chalcone in rats. J Agric Food Chem. 2009 Jul 22;57 (14) :6432-7.