CRM1 (Acetyl Lys568) Polyclonal Antibody

Rabbit Anti-CRM1 (Acetyl Lys568) Polyclonal Antibody

Product Specifications

Background

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES) -dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. Exportin 1 also regulates NFAT and AP-1.

CAS Number

9007-83-4

Product Name Alternative

XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog

Gene ID

7514

Accession Number

O14980

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from the Internal region of human CRM1 around the acetylation site of K568

Clonality

Polyclonal

Tag

Exportin-1

Applications

WB, ELISA

Field of Research

Epigenetics#Signal Transduction

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

125kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when non-acetylation at K568.

Observed Molecular Weight

125

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.