Palomid 529
Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes.
Product Specifications
CAS Number
914913-88-5
Product Name Alternative
P529
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; mTOR
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Palomid-529.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(OCC2=CC=C(C=C2)OC)C=C3C(C4=C(C(O3)=O)C=C(C(C)O)C=C4)=C1
Molecular Formula
C24H22O6
Molecular Weight
406.43
Precautions
H301
References & Citations
[1]Xue Q, et al. Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res, 2008, 68 (22), 9551-9557.|[2]Weinberg MA, et al. RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes. Anticancer Drugs. 2016 Jul;27 (6) :475-87.|[3]Gravina GL, et al. The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel andcisplatin in aggressive and hormone-refractory prostate cancer cells. Endocr Relat Cancer. 2011 Jul 1;18 (4) :385-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTORC1; mTORC2
Available Sizes
Frequently Asked Questions
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