Palomid 529

Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes.

Product Specifications

CAS Number

[914913-88-5]

Product Name Alternative

P529

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; mTOR

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Palomid-529.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OCC2=CC=C(C=C2)OC)C=C3C(C4=C(C(O3)=O)C=C(C(C)O)C=C4)=C1

Molecular Formula

C24H22O6

Molecular Weight

406.43

Precautions

H301

References & Citations

[1]Xue Q, et al. Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res, 2008, 68 (22), 9551-9557.|[2]Weinberg MA, et al. RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes. Anticancer Drugs. 2016 Jul;27 (6) :475-87.|[3]Gravina GL, et al. The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel andcisplatin in aggressive and hormone-refractory prostate cancer cells. Endocr Relat Cancer. 2011 Jul 1;18 (4) :385-400.