GlyH-101

GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current[1][2].

Product Specifications

CAS Number

[328541-79-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GlyH-101.html

Purity

99.68

Solubility

DMSO : ≥ 58 mg/mL

Smiles

O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC3=CC=CC=C3C=C2

Molecular Formula

C19H15Br2N3O3

Molecular Weight

493.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124 (2) :125-37.|[2]Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR (inh) -172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr;333 (1) :60-9.|[3]Barman PP, et al. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochem Biophys Res Commun. 2011 Apr 29;408 (1) :12-7.|[4]Melis N, et al. Revisiting CFTR inhibition: a comparative study of CFTRinh -172 and GlyH-101 inhibitors. Br J Pharmacol. 2014 Aug;171 (15) :3716-27.|[5]Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124 (2) :125-37.