DMNQ

DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production[1][2].

Product Specifications

CAS Number

[6956-96-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Reactive Oxygen Species (ROS) ; ROS Kinase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dmnq.html

Purity

99.8

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(OC)=C(C(C2=CC=CC=C21)=O)OC

Molecular Formula

C12H10O4

Molecular Weight

218.21

Precautions

H315, H319, H335

References & Citations

[1]Watanabe N, et al. Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells. Arch Biochem Biophys. 2003 Mar 1;411 (1) :145-57.|[2]Shi MM, et al. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J Biol Chem. 1994 Oct 21;269 (42) :26512-7.