Oxyfluorfen

Oxyfluorfen is a pre- and post-emergence diphenyl ether herbicide to control annual broad-leaved and grass weeds. Oxyfluorfen is a protoporphyrinogen oxidase inhibitor and inhibits photosynthesis by blocking chlorophyll synthesis. Oxyfluorfen can inhibit cell growth. Oxyfluorfen induces DNA damage and exhibits toxicity toward aquatic organisms such as Paramisgurnus dabryanus. Oxyfluorfen has genome-level deleterious effects on fish that can lead to stunted skeletal growth. Oxyfluorfen induces transverse limb deficiency or craniosynostosis[1][2].

Product Specifications

CAS Number

[42874-03-3]

UNSPSC

12352005

Hazard Statement

H400, H410

Target

Herbicide; Protoporphyrinogen IX oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/oxyfluorfen.html

Concentration

10mM

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C1=CC=C(OC2=CC=C([N+]([O-])=O)C(OCC)=C2)C(Cl)=C1)(F)F

Molecular Formula

C15H11ClF3NO4

Molecular Weight

361.70

Precautions

H400, H410

References & Citations

[1]Chi Wu, et al. Sorption, Degradation and Bioavailability of Oxyfluorfen in Biochar-Amended Soils. Sci Total Environ. 2019 Mar 25;658:87-94.|[2]E Warabi, et al. Resistance of a Soybean Cell Line to Oxyfluorfen by Overproduction of Mitochondrial Protoporphyrinogen Oxidase. Pest Manag Sci. 2001 Aug;57 (8) :743-8.|[3]F. Peixoto, et al., Toxicological effects of oxyfluorfen on oxidative stress enzymes in tilapia Oreochromis niloticus, Pesticide Biochemistry and Physiology, Volume 85, Issue 2, 2006, Pages 91-96, ISSN 0048-3575.|[4]Stagg, N. J., et al., (2012) . Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects. Toxicological sciences: an official journal of the Society of Toxicology, 128 (2), 334–345.