CD10 Monoclonal Antibody
Mouse Anti-CD10 Monoclonal Antibody
Product Specifications
Background
MME encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . Membrane metalloendopeptidase is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. Membrane metalloendopeptidase is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. Membrane metalloendopeptidase is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of MME is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
CAS Number
9007-83-4
Product Name Alternative
MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10
Gene ID
4311
Accession Number
P08473
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Tag
Neprilysin
Applications
IF, IHC
Purification Method
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous CD10 proteins.
Product Datasheet
https://www.abbkine.com/datasheet/ABM40072.pdf
Formulation
Liquid solution
Buffer pH
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200; IHC 1:50-200
Other Product Names
MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Mouse
Accession Number URL
http://www.uniprot.org/uniprot/P08473
Isotype
Mouse IgG1
Available Sizes
Curated Selection
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