HK-2-IN-2
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle[1].
Product Specifications
CAS Number
3056278-80-6
UNSPSC
12352005
Target
Hexokinase; Microtubule/Tubulin; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-190.html
Smiles
O=C(C1=CC=CN=C1)/C=C/C2=CN(S(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O)C4=C2C=C(N5CCOCC5)C=C4
Molecular Formula
C26H22N4O6S
Molecular Weight
518.54
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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