RBP1 rabbit pAb

RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550) . Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]) .[supplied by OMIM, Nov 2010]

Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cytoplasm, cytoskeleton, spindle pole . Nucleus . Mitochondrion . Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity) . Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity) . Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277) . Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010) . The region involved in membrane association could form transmembrane domains and expose a par