RAGP1 rabbit pAb

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Product Specifications

Background

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP) -binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt

P46060

Swiss Prot

P46060

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

64kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

64kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus, nucleoplasm . Nucleus envelope . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602) . Targeted to the nuclear pores after sumoylation (PubMed:11854305) . During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602) . Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305) . Mitotic location also requires sumoylation (PubMed:11854305) . .