LRIG1 rabbit pAb
Domain: The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted. function: Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. induction: By EGF. similarity: Contains 17 LRR (leucine-rich) repeats. similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. subunit: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4. tissue specificity: Widely expressed.
Product Specifications
Background
UniProt
Q96JA1
Swiss Prot
Q96JA1
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
LRIG1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
120kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
120kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Gene ID (Human)
26018
Available Sizes
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