TIAM1 rabbit pAb

Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. similarity: Belongs to the TIAM family. similarity: Contains 1 DH (DBL-homology) domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 PH domain. similarity: Contains 1 RBD (Ras-binding) domain. similarity: Contains 2 PH domains. subunit: Interacts with BAIAP2. tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Product Specifications

Background

Function:Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA., similarity:Belongs to the TIAM family., similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 PH domain., similarity:Contains 1 RBD (Ras-binding) domain., similarity:Contains 2 PH domains., subunit:Interacts with BAIAP2., tissue specificity:Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

UniProt

Q13009

Swiss Prot

Q13009

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

175kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

175kD

Fragment

IgG

Subcellular Location

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Detected at the boundary between cells with actin-rich protrusions (By similarity) . Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. .