MC-betaglucuronide-MMAE-1
MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.
Product Specifications
CAS Number
[1703778-92-0]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-betaglucuronide-mmae-1.html
Purity
99.23
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@H]1[C@H](O)[C@@H](O)[C@H](OC2=C(NC(CCNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N4[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C5=CC=CC=C5)=O)CCC4)=O)=O)C(C)C)=O)=O)C=C2)O[C@@H]1C(O)=O
Molecular Formula
C66H98N8O20
Molecular Weight
1323.53
References & Citations
[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16 (3), 888-897.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Auristatin
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV672701 1.0 µg DNA
PFKL Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 
364491 200 µL
OPTN (Optineurin, NRP, FIP2, GLC1E, HIP7, HYPL, TFIIIA-INTP, Glaucoma 1, Open Angle, E (Adult-Onset), Huntingtin-interacting protein 7, Optic neuropathy-inducing protein, E3-14.7K-interacting protein)
Sign In for Pricing
View Details LV672498 1.0 µg DNA
BCAR1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
Sign In for Pricing
View Details