MC-betaglucuronide-MMAE-1
MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.
Product Specifications
CAS Number
[1703778-92-0]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-betaglucuronide-mmae-1.html
Purity
99.23
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@H]1[C@H](O)[C@@H](O)[C@H](OC2=C(NC(CCNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N4[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C5=CC=CC=C5)=O)CCC4)=O)=O)C(C)C)=O)=O)C=C2)O[C@@H]1C(O)=O
Molecular Formula
C66H98N8O20
Molecular Weight
1323.53
References & Citations
[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16 (3), 888-897.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Auristatin
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
NBP2-89555AF405 0.1 mL
Rabbit Monoclonal RELT/TNFRSF19L Antibody (111) [Alexa Fluor 405]
Sign In for Pricing
View Details 464088-01 25 mg
(R) -tert-Butyl (1- ((4-Methylquinazolin-2-yl) methyl) piperidin-3-yl) carbamate
Sign In for Pricing
View Details 
464088-02 50 mg
(R) -tert-Butyl (1- ((4-Methylquinazolin-2-yl) methyl) piperidin-3-yl) carbamate
Sign In for Pricing
View Details