D5R agonist 1

D5R agonist 1 (Compound 5j) is a selective, orally active and BBB penetrable D5R partial agonist (EC50: 269.7 nM) . D5R agonist 1 enhances the cognition in the Scopolamine (HY-N0296) -induced amnesia model[1].

Product Specifications

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d5r-agonist-1.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(C2=CC(OC)=C(OC)C=C2OC)=CC(C3=CC=C(I)C=C3)=N1

Molecular Formula

C19H18IN3O3

Molecular Weight

463.27

References & Citations

[1]Kumar S, et al. Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists. Bioorg Chem. 2024 Sep 7;153:107809.