MRGX2 rabbit pAb

Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q)-coupled. similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. tissue specificity: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.