MRGRD rabbit pAb

Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca (2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G (q) and G (i). similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. subcellular location: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.