FPR2 rabbit pAb

Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). similarity: Belongs to the G-protein coupled receptor 1 family. tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Product Specifications

Background

Function:Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) ., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

UniProt

P25090

Swiss Prot

P25090

Reactivity

Human; Rat; Mouse; ; Swine

Immunogen

Synthesized peptide derived from human protein . at AA range: 130-210

Target

FPR2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

38kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

38kD

Fragment

IgG

Subcellular Location

Cell membrane ; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470) . Also internalized in the presence of humanin (PubMed:15465011) . .