FPR2 rabbit pAb

Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). similarity: Belongs to the G-protein coupled receptor 1 family. tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.