GITR Extracellular Domain (human, recombinant)

<strong>GITR Extracellular Domain (human, recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2017354_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 16 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> CD357, GITR-D, Glucocorticoid-induced TNFR-related Protein, TNF Receptor Superfamily Member 18, TNFRS18, Tumor Necrosis Factor Receptor Superfamily Member 18_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Tigue NJ, Bamber L, Andrews J, Ireland S, Hair J, Carter E, Sridharan S, Jovanović J, Rees DG, Springall JS, Solier E, Li YM, Chodorge M, Perez-Martinez D, Higazi DR, Oberst M, Kennedy M, Black CM, Yan L, Schwickart M, Maguire S, Cann JA, de Haan L, Young LL, Vaughan T, Wilkinson RW, Stewart R. MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential Oncoimmunology. 2017 Feb 3;6(3):e1280645._x000D_ 2: Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS. Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted J Immunol. 2015 Nov 15;195(10):4721-9._x000D_ 3: Draghiciu O, Lubbers J, Nijman HW, Daemen T. Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy Oncoimmunology. 2015 Feb 3;4(1):e954829._x000D_ 4: Morillon YM 2nd, Hammond SA, Durham NM, Schlom J, Greiner JW. Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein Oncotarget. 2017 Sep 7;8(43):73469-73482._x000D_ 5: Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati G, Riccardi C. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6216-21._x000D_ 6: Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI. Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5465-70._x000D_ 7: Shin HH, Lee MH, Kim SG, Lee YH, Kwon BS, Choi HS. Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage FEBS Lett. 2002 Mar 13;514(2-3):275-80._x000D_ 8: Ko HJ, Kim YJ, Kim YS, Chang WS, Ko SY, Chang SY, Sakaguchi S, Kang CY. A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model Cancer Res. 2007 Aug 1;67(15):7477-86._x000D_ 9: Shen P, Su Z, Wang S, Xu H. [Bioinformatic analysis of mouse glucocorticoid-induced tumor necrosis factor receptor-related protein] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Nov;30(11):1205-8._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/37795079">10: Fromm G, de Silva S, Schreiber TH. Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists Front Immunol. 2023 Sep 19;14:1236332. </a>_x000D_ _x000D_ <strong>Products Related to GITR Extracellular Domain (human, recombinant) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>