APTX rabbit pAb

Aprataxin (APTX) Homo sapiens This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010],

Product Specifications

Background

UniProt

Q7Z2E3

Swiss Prot

Q7Z2E3

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human protein . at AA range: 11-60

Target

APTX

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

39kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

39kD

Fragment

IgG

Subcellular Location

Nucleus, nucleoplasm . Nucleus, nucleolus . Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage (PubMed:15380105) . Colocalizes with MDC1 at sites of DNA double-strand breaks (PubMed:20008512) . Interaction with NCL is required for nucleolar localization (PubMed:16777843) . .; [Isoform 12]: Cytoplasm .