PARP9 rabbit pAb

Catalytic activity: NAD (+) + (ADP-D-ribosyl) (n)-acceptor = nicotinamide + (ADP-D-ribosyl) (n+1)-acceptor. miscellaneous: Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. similarity: Contains 1 PARP catalytic domain. similarity: Contains 2 Macro domains. subunit: Interacts with BBAP. tissue specificity: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.

Product Specifications

Background

Catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., miscellaneous:Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration., similarity:Contains 1 PARP catalytic domain., similarity:Contains 2 Macro domains., subunit:Interacts with BBAP., tissue specificity:Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.

UniProt

Q8IXQ6

Swiss Prot

Q8IXQ6

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 450-530

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

93kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

93kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytosol . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:16809771) . Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788) . Export to the cytosol depends on the interaction with DTX3L (PubMed:16809771) . Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742) . .