SPY4 rabbit pAb

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014],

Product Specifications

Background

UniProt

Q9C004

Swiss Prot

Q9C004

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 230-310

Target

SPY4

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

32kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

32kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity) . Colocalizes with TESK1 in vesicular spots in the cytoplasm (PubMed:15584898) . .