LIGO1 rabbit pAb
Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. PTM: N-glycosylated. Contains predominantly high-mannose glycans. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 13 LRR (leucine-rich) repeats. subunit: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19. tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
Product Specifications
Background
Gene ID
84894
UniProt
Q96FE5
Cellular Locus
Cell membrane ; Single-pass type I membrane protein.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 370-450
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
68kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES11241-1.pdf
Observed Molecular Weight
68 kD
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Gene ID (Human)
84894
SwissProt (Human)
Q96FE5
Available Sizes
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