LIGO1 rabbit pAb

Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. PTM: N-glycosylated. Contains predominantly high-mannose glycans. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 13 LRR (leucine-rich) repeats. subunit: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19. tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.