INSRR rabbit pAb

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. function: This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 3 fibronectin type-III domains. subunit: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.