TNKS1 rabbit pAb

Catalytic activity: NAD (+) + (ADP-D-ribosyl) (n)-acceptor = nicotinamide + (ADP-D-ribosyl) (n+1)-acceptor. function: May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length. PTM: ADP-ribosylated (-auto). PTM: Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. similarity: Contains 1 PARP catalytic domain. similarity: Contains 1 SAM (sterile alpha motif) domain. similarity: Contains 15 ANK repeats. subcellular location: Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. subunit: Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. tissue specificity: Ubiquitous; highest levels in testis.