R4RL2 rabbit pAb

Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. PTM: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. similarity: Belongs to the Nogo receptor family. similarity: Contains 8 LRR (leucine-rich) repeats. subcellular location: Localized to the surface of neurons, including axons. tissue specificity: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.

Product Specifications

Background

Function:May play a role in regulating axonal regeneration and plasticity in the adult central nervous system., PTM:Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein., similarity:Belongs to the Nogo receptor family., similarity:Contains 8 LRR (leucine-rich) repeats., subcellular location:Localized to the surface of neurons, including axons., tissue specificity:Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.

UniProt

Q86UN3

Swiss Prot

Q86UN3

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 290-370

Target

R4RL2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

46kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

46kD

Fragment

IgG

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor . Membrane raft . Cell projection, dendrite . Perikaryon . Cell projection, axon . Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. .