ANQ-11125

ANQ-11125 is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit[1][2].

Product Specifications

CAS Number

[153966-48-4]

UNSPSC

12352209

Target

Motilin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/anq-11125.html

Solubility

H2O

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CC=CC=C4)N

Molecular Formula

C86H125N19O21

Molecular Weight

1761.03

References & Citations

[1]Depoortere I, et, al. Antagonistic properties of [Phe3, Leu13]porcine motilin. Eur J Pharmacol. 1995 Nov 24; 286 (3) :241-7.|[2]Peeters TL, et, al. The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem Biophys Res Commun. 1994 Jan 28; 198 (2) : 411-6.