GPNMB rabbit pAb

Glycoprotein nmb (GPNMB) Homo sapiens The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q14956

Swiss Prot

Q14956

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Target

GPNMB

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

62kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

62kD

Fragment

IgG

Subcellular Location

Cell membrane; Single-pass type I membrane protein . Melanosome membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .