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SCR-1481B1 (free base)

SCR-1481B1 free base, also known as Metatinib free base, is a small molecule receptor kinase inhibitor that targets both c-MET and vascular endothelial growth factor receptor 2 (VEGFR2) [1].

Product Specifications

CAS Number

[1174161-69-3]

Product Name Alternative

Metatinib (free base) ; c-Met inhibitor 2 (free base)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-Met/HGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/scr-1481b1-free-base.html

Purity

99.99

Solubility

DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CN(COP(O)(O)=O)C=C(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C(Cl)C(N)=NC=C4)C(F)=C3

Molecular Formula

C24H18ClF2N4O7P

Molecular Weight

578.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Cheng K, et al. Safety, Efficacy, and Pharmacokinetics of Metatinib Tromethamine Tablet in Patients with Advanced Refractory Solid Tumors: A Phase I Clinical Trial. Oncologist. 2021 Aug;26 (8) :649-e1313.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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