HES4 rabbit pAb

Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins. function: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. similarity: Contains 1 basic helix-loop-helix (bHLH) domain. similarity: Contains 1 Orange domain. subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.