α-Zearalenol

α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1].

Product Specifications

CAS Number

[36455-72-8]

UNSPSC

12352005

Hazard Statement

H302, H314, H351, H361, H371, H412

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alpha-zearalenol.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C2C(O[C@H](CCC[C@@H](CCC/C=C/C2=CC(O)=C1)O)C)=O

Molecular Formula

C18H24O5

Molecular Weight

320.38

Precautions

H302, H314, H351, H361, H371, H412

References & Citations

[1].Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28 (4) :239-242.|[2]Marin DE, et al. Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites. Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392 (8) :937-947.|[3]Nittoli AC, et al. Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach. Metabolomics. 2018 Feb 14;14 (3) :33.