NRBP rabbit pAb

Caution: Author states that kinase activity observed in PubMed: 11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive. Domain: The protein kinase domain is predicted to be catalytically inactive. function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. similarity: Contains 1 protein kinase domain. subcellular location: Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia. subunit: Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm. tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis.