PKN3 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Domain: The C1 domain does not bind the diacylglycerol (DAG). enzyme regulation: Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation. function: Contributes to invasiveness in malignant prostate cancer. PTM: Autophosphorylated. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 1 protein kinase domain. similarity: Contains 3 REM (Hr1) repeats. subcellular location: Nuclear and perinuclear Golgi region. tissue specificity: Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.