MUL1 rabbit pAb

Domain: The zinc finger domain is required for E3 ligase activity. function: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 RING-type zinc finger. subcellular location: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. subunit: Homooligomer. Interacts with MAP3K7/TAK1. tissue specificity: Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.