MIB2 rabbit pAb

Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. induction: Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene. pathway: Protein modification; protein ubiquitination. PTM: Ubiquitinated. Possibly via autoubiquitination. similarity: Contains 1 ZZ-type zinc finger. similarity: Contains 2 MIB/HERC2 domains. similarity: Contains 2 RING-type zinc fingers. similarity: Contains 9 ANK repeats. subcellular location: Colocalizes with endosomal compartments. subunit: Interacts with actin monomer. tissue specificity: Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.