MCM9 rabbit pAb
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010],
Product Specifications
Background
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
UniProt
Q9NXL9
Swiss Prot
Q9NXL9
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
125kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
125kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Colocalizes to nuclear foci with RPA1 following DNA damage (PubMed:23401855) . Localizes to double-stranded DNA breaks (PubMed:23401855) . Recruited to chromatin by MSH2 (PubMed:26300262) . .
Gene ID (Human)
254394
Available Sizes
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