JAML1 rabbit pAb

Domain: The Ig-like V-type domain 2 mediates interaction with CXADR. function: May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. induction: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. similarity: Belongs to the immunoglobulin superfamily. similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains. subcellular location: Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN. subunit: Interacts with CXADR. tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus.