WWTR1 rabbit pAb

Domain: Binds to transcription factors via its WW domain. Domain: The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes. function: Functions as a transcriptional coactivator. PTM: Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. similarity: Contains 1 WW domain. subcellular location: Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. subunit: Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. tissue specificity: Highly expressed in kidney, heart, placenta and lung.

Product Specifications

Background

Domain:Binds to transcription factors via its WW domain., domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes., function:Functions as a transcriptional coactivator., PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export., similarity:Contains 1 WW domain., subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ., subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP., tissue specificity:Highly expressed in kidney, heart, placenta and lung.

UniProt

Q9GZV5

Swiss Prot

Q9GZV5

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Target

WWTR1

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

44kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

44kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity) . When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity) . Can be retained in the nucleus by MED15 (PubMed:18568018) . Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499) . At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity) . .