ASPM rabbit pAb

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011],

Product Specifications

Background

UniProt

Q8IZT6

Swiss Prot

Q8IZT6

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 1230-1310

Target

ASPM

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Concentration

1 mg/ml

Dilution

IHC-p 1:50-300

Buffer

-20°C/1 year

Molecular Weight

382kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

382kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity) . Localizes to spindle poles during mitosis (PubMed:19690332) . Associates with microtubule minus ends (By similarity) . .