UBP6 rabbit pAb

Catalytic activity: Ubiquitin C-terminal thioester + H (2)O = ubiquitin + a thiol. Disease: Involved in tumorigenesis. function: Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. miscellaneous: The USP6 gene only exists in the primate lineage. similarity: Belongs to the peptidase C19 family. similarity: Contains 1 Rab-GAP TBC domain. tissue specificity: Testis specific. Expressed in various cancer cell lines.

Product Specifications

Background

Catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., disease:Involved in tumorigenesis., function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity., miscellaneous:The USP6 gene only exists in the primate lineage., similarity:Belongs to the peptidase C19 family., similarity:Contains 1 Rab-GAP TBC domain., tissue specificity:Testis specific. Expressed in various cancer cell lines.

UniProt

P35125

Swiss Prot

P35125

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

154kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

154kD

Fragment

IgG

Subcellular Location

Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.