ZO1 rabbit pAb

This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, tight junction . Cell junction . Cell junction, gap junction. Cell projection, podosome . Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316) . At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113) . Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225) . .